The American has a strong slate of non-conference games against the P4 over the next 5 years headlines by USF, Temple, Tulane and Tulsa. Of note:
- The American has 18 games against P4 teams in 2025 (6 home, 12 road)
- Tulsa has the most upcoming P4 games with 8, thanks mostly to 5 games against Oklahoma State
- Temple has arguably the most impressive home slate with Oklahoma, Penn State and Duke all traveling to Philadelphia
- USF, ECU, Temple and Tulsa have the most P4 home games with 3 each
- Army, FAU, UAB and UTSA have ZERO home games scheduled against P4 teams in the next 5 years
- Kudos to Charlotte for getting home games against UNC and Ole Miss in 2025 and 2026
2025 | 2026 | 2027 | 2028 | 2029 | |
| South Florida | at Florida at Miami, FL | at Alabama | Louisville | at Miami, FL | North Carolina St. Notre Dame |
| Army | at Kansas State | at Wake Forest | at Boston College | at Missouri | |
| Charlotte | North Carolina at Georgia | Ole Miss at Louisville | at Ole Miss | at Ohio State | |
| East Carolina | at North Carolina St BYU | Wake Forest | North Carolina St at Wake Forest | at Clemson | |
| Florida Atlantic | at Maryland | at Missouri | at UCF | ||
| Memphis | Arkansas | at Arkansas | Mississippi State at Arkansas | at Mississippi State | |
| Navy | at Notre Dame | Notre Dame | at Notre Dame | Notre Dame | at Notre Dame |
| North Texas | Texas Tech | at Baylor | Baylor | ||
| Rice | Houston | at LSU | |||
| Temple | Oklahoma at Georgia Tech | Penn State | at Penn State | at Oklahoma Duke | at Miami, FL |
| Tulane | Duke at Ole Miss | at Duke at Kansas State | at Wake Forest | at Iowa State | Iowa State |
| Tulsa | at Oklahoma State | Oklahoma State at Arkansas | Arkansas at Oklahoma State | Oklahoma State | at Arkansas at Oklahoma State |
| UAB | at Tennessee | ||||
| UTSA | at Texas A&M | at Texs | at LSU | at Texas |
